A video found on one of the devices allegedly shows two children striking each other with a belt, while another series of photos depicts two of the children as siblings engaged in sexually explicit activity.Īccording to the Al Cannon Detention Center website, Eachus was booked on the afternoon of Oct. Detailed descriptions of the dozens of photos and videos allegedly found on these devices include depictions of more than 40 children that appear to vary in age from six to 16 years old.ĭescriptions accompanying the photos include terms like “for the first time” and “romantic mouse,” according to arrest affidavits, which go on to explain that “Siberian Mouse” is used to describe a known series of photos that depict a child in a state of sexually explicit nudity and is often traded online as child pornography. The affidavit goes on to state that Eachus confessed to his employer that he had used computer equipment owned by the company and assigned exclusively to him to transfer files among his personally owned external storage devices while he was working at Boeing’s North Charleston facility.Īccording to the affidavit, Eachus “voluntarily surrendered the external storage devices to his employer,” which were then handed over to the Sheriff’s Office. 7, a detective with the Charleston County Sheriff’s Office was notified by Boeing that several digital files containing “depictions of minors engaged in sexual activity” were located on external storage devices belonging to employee Pitak Ot Eachus, according to an arrest affidavit. Fogh, J Giovanella, B.C.A 47-year-old North Charleston man faces 10 charges of third-degree sexual exploitation of a minor after allegedly using company equipment to transfer child pornography. The Nude Mouse in Experimental and Clinical Research (Vol.2).The Nude Mouse in Experimental and Clinical Research (Vol.1).In controlled, germ free environments and with antibiotic treatments found in many laboratories that routinely use nude mice, they can live almost as long as normal mice (18 months to two years). The life span of nude mice is normally 6 months to a year. Since nude females have underdeveloped mammary glands and are unable to effectively nurse their young, nude males are bred with heterozygous females. ) Mice with a targeted deletion in the FOXN1 ("knockout" mice) also show the "nude" phenotype. (Humans with mutations in FOXN1 also are athymic and immune deficient. Nude mice have a spontaneous deletion in the FOXN1 gene. For these reasons, nude mice are less popular in research today. In addition, knockout mice with more complete defects in the immune system have been constructed (e.g. Most strains of nude mice are slightly "leaky" and do have a few T cells, especially as they age. Moreover, the absence of functioning T cells prevents nude mice from rejecting not only allografts (grafts of tissue from other mice) but also xenografts (grafts of tissue from another species). graft rejection (requires both CD4+ and CD8+ T cells)īecause of the above features, nude mice have served in the laboratory to gain insights into the immune system, leukemia, solid tumors, AIDS and other forms of immune deficiency as well as leprosy.killing of virus-infected or malignant cells (requires CD8+ cytotoxic T cells).delayed-type hypersensitivity responses (require CD4+ T cells).cell-mediated immune responses, which require CD4+ and/or CD8+ T cells.antibody formation that requires CD4+ helper T cells.Therefore they are unable to mount many types of adaptive immune responses, including: ![]() Because they lack a thymus, nude mice cannot generate mature T lymphocytes. Grist at Ruchill Hospital's Brownlee virology laboratory in Glasgow. Nude mice were first discovered in 1962 by Dr. Then in 2000, the gene responsible for the mutation was identified as a member of the Fox gene family and the nomenclature was updated to Foxn1nu. Originally they were described as nu and this was updated to Hfh11nu when the mutated gene was identified as a mutation in the HNF-3/forkhead homolog 11 gene. The nomenclature for the nude mouse has changed several times since their discovery. The genetic basis of the nude mouse mutation is a disruption of the FOXN1 gene. These xenografts are commonly used in research to test new methods of imaging and treating tumors. The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it mounts no rejection response. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname. Lab mouse strain lacking immunity and fur A nude mouseĪ nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells.
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